The Epidemiology, Cause, and Prognosis of Painful Tic Convulsif Syndrome: An Individual Patient Data Analysis of 192 Cases

Characterized by the coexistence of trigeminal neuralgia and ipsilateral hemifacial spasm (HFS), painful tic convulsif (PTC) is a rare entity that has not yet been systematically studied. To explore epidemiology, cause, prognosis, prognosis predictors PTC. We searched PubMed, Web Science, Cochrane Library for relevant studies published between establishment library July 1, 2020. Information on demographics, causes, specific interventions, intervention outcomes was extracted. first performed descriptive analysis surgical Univariate multivariate regression methods were used to potential predictors. Further, 2-step meta-analysis method validate identified factors. Overall, 57 reports including 192 cases with PTC included in analysis. The median age patients 54 years (range, 44–62 years), more being female (P < 0.001), initiated as HFS = 0.005), affected left side 0.045). vertebrobasilar artery contributes >65% causes single vascular compression Anterior inferior cerebellar artery/posterior involvement (odds ratio, 4.050; 95% confidence interval, 1.091–15.031) older 0.008) predict freedom from symptoms recurrence after microvascular decompression, respectively. occurs middle-aged women 40 60 old, initiates HFS, affects side. Vertebrobasilar most common cause Microvascular decompression effectively treated PTC, cure rate >80%. predicts successful surgery recurrence.